Stellate ganglion stimulation causes spatiotemporal changes in ventricular repolarization in pig.

ABSTRACT:

Background

Dispersion in ventricular repolarization is relevant for arrhythmogenesis.

Objective

The purpose of this study was to determine the spatiotemporal effects of sympathetic stimulation on ventricular repolarization.

Methods

In 5 anesthetized female open-chest pigs, ventricular repolarization was measured from the anterior, lateral, and posterior walls of the left ventricle (LV) and right ventricle using up to 40 transmural plunge needles (4 electrodes each) before and after left stellate ganglion stimulation (LSGS) and right stellate ganglion stimulation. In addition, LSGS was performed in 3 pigs (2 male, 1 female) before and after verapamil (5-10 mg/h) administration.

Results

LSGS yielded a biphasic response in repolarization in the lateral and posteri

SUBMITTER: Meijborg VMF 

PROVIDER: S-EPMC7196037 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature