The "histological replacement growth pattern" represents aggressive invasive behavior in liver metastasis from pancreatic cancer.

ABSTRACT:

Background

In the case of liver metastasis (LM), tumors showing the replacement growth pattern (RGP), in which metastatic cells infiltrate and replace hepatocytes with minimal desmoplastic reaction and inflammatory cell infiltration, associate with a poor prognosis. The heterogeneity, frequency, and prognostic value of the RGP in LM from pancreatic cancer (PCa) are not well known.

Methods

In the circumference of treatment-naïve resected LMs from patients with PCa, the heterogeneity of the GP was assessed. Next, the clinicopathological features of LMs showing the RGP in needle biopsy specimens were investigated in patients with treatment-naïve advanced PCa.

Results

Thirteen of the 14 (93%) in all resected LMs and 7 of the 9 (78%) in RGP component GP in resected LMs sho

SUBMITTER: Watanabe K 

PROVIDER: S-EPMC7196051 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature