SGLT2 inhibition reduces atherosclerosis by enhancing lipoprotein clearance in Ldlr^-/- type 1 diabetic mice.

ABSTRACT:

Background and aims

Leukocytosis, particularly monocytosis, has been shown to promote atherosclerosis in both diabetic and non-diabetic mouse models. We previously showed that hyperglycemia independently promotes monocytosis and impairs the resolution of atherosclerosis. Since patients with chronic diabetes often develop dyslipidemia and also have increased risk for atherosclerosis, we sought to examine how controlling blood glucose affects atherosclerosis development in the presence of severe hyperlipidemia.

Methods

Diabetes was induced using streptozotocin (STZ) in low density lipoprotein receptor (Ldlr) knockout (Ldlr^-/-) mice after which they were fed a high-cholesterol diet for 4 weeks. Control and diabetic mice were treated with vehicle or sodium glucose cot

SUBMITTER: Al-Sharea A 

PROVIDER: S-EPMC7196281 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature