Non-invasive ultrasonic neuromodulation of neuronal excitability for treatment of epilepsy.

ABSTRACT: Non-invasive low-intensity pulsed ultrasound has been employed for direct neuro-modulation. However, its range and effectiveness for different neurological disorders have not been fully elucidated. Methods: We used multiple approaches of electrophysiology, immunohistochemistry, and behavioral tests as potential epilepsy treatments in non-human primate model of epilepsy and human epileptic tissues. Low-intensity pulsed ultrasound with a frequency of 750 kHz and acoustic pressure of 0.35 MPa (the spatial peak pulse average intensity, I_SPPA = 2.02 W/cm²) were delivered to the epileptogenic foci in five penicillin-induced epileptic monkey models. An ultrasound neuro-modulation system with a frequency of 28 MHz and acoustic pressure of 0.13 MPa (I_SPPA = 4

SUBMITTER: Lin Z 

PROVIDER: S-EPMC7196311 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature