Alcohol and Tobacco Use in Relation to Mammographic Density in 23,456 Women.

ABSTRACT:

Background

Percent density (PD) is a strong risk factor for breast cancer that is potentially modifiable by lifestyle factors. PD is a composite of the dense (DA) and nondense (NDA) areas of a mammogram, representing predominantly fibroglandular or fatty tissues, respectively. Alcohol and tobacco use have been associated with increased breast cancer risk. However, their effects on mammographic density (MD) phenotypes are poorly understood.

Methods

We examined associations of alcohol and tobacco use with PD, DA, and NDA in a population-based cohort of 23,456 women screened using full-field digital mammography machines manufactured by Hologic or General Electric. MD was measured using Cumulus. Machine-specific effects were estimated using linear regression, and combined using

SUBMITTER: McBride RB 

PROVIDER: S-EPMC7196522 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature