Methylphenidate affects task-switching and neural signaling in non-human primates.

ABSTRACT:

Rationale

Low doses of psychostimulants such as methylphenidate (MPH), which increase extracellular dopamine and norepinephrine by inhibiting their reuptake, are the most commonly used treatment for attention deficit hyperactivity disorder (ADHD). Therapeutic doses of these drugs may improve focused attention at the expense of hindering other cognitive functions, including the ability to adapt behavior in response to changing circumstances-cognitive flexibility. Cognitive flexibility is thought to depend on proper operation of the prefrontal cortex (PFC) and is also linked to reward processing, which is dopamine-dependent. Additionally, reward outcome signals have been recorded from the PFC.

Objectives

This study tested the hypothesis that therapeutic doses of MPH impair cog

SUBMITTER: Rajala AZ 

PROVIDER: S-EPMC7196524 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature