Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC7196633 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Liu Jie J Kozhaya Lina L Torres Victor J VJ Unutmaz Derya D Lu Min M
The Journal of biological chemistry 20200316 18
The rapid emergence and dissemination of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) strains poses a major threat to public health. MRSA possesses an arsenal of secreted host-damaging virulence factors that mediate pathogenicity and blunt immune defenses. Panton-Valentine leukocidin (PVL) and α-toxin are exotoxins that create lytic pores in the host cell membrane. They are recognized as being important for the development of invasive MRSA infections and are thus potential targets f ...[more]