A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli.

ABSTRACT: Bacterial specialized metabolites are increasingly recognized as important factors in animal-microbiome interactions: for example, by providing the host with chemical defenses. Even in chemically rich animals, such compounds have been found to originate from individual members of more diverse microbiomes. Here, we identified a remarkable case of a moderately complex microbiome in the sponge host Mycale hentscheli in which multiple symbionts jointly generate chemical diversity. In addition to bacterial pathways for three distinct polyketide families comprising microtubule-inhibiting peloruside drug candidates, mycalamide-type contact poisons, and the eukaryotic translation-inhibiting pateamines, we identified extensive biosynthetic potential distributed among a broad phylogenetic ran

SUBMITTER: Rust M 

PROVIDER: S-EPMC7196800 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature