Risk-benefit analysis of tuberculosis infection testing for household contact management in high-burden countries: a mathematical modelling study.

ABSTRACT:

Background

Preventive therapy for tuberculosis reduces the risk of disease in people who have been infected but who are not sick. Countries with a high burden of tuberculosis that are expanding preventive therapy use must decide how tuberculosis infection testing should be used for risk stratification among household contacts of patients with tuberculosis.

Methods

We modelled the risks of tuberculosis disease and severe adverse events, comparing the following two preventive therapy strategies: preventive therapy for all household contacts, or preventive therapy for only household contacts with a positive tuberculin skin test (TST) result. We used data from clinical trials and literature on tuberculosis natural history to model outcomes, assuming different preventive therapy

SUBMITTER: Yuen CM 

PROVIDER: S-EPMC7196883 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature