Alteration of brain temperature and systemic inflammation in Parkinson's disease.

ABSTRACT:

Objectives

Parkinson's disease (PD) is known to be related to various factors, including neuroinflammation, increased oxidative stress, and brain temperature alteration. We aimed to evaluate the correlation between these factors using diffusion-weighted imaging (DWI) thermometry and blood tests of systemic inflammation.

Methods

From July 2012 to Jun 2017, 103 patients with PD (44 men and 59 women; mean age, 60.43 ± 9.12 years) and 106 sex- and age-matched healthy volunteers (48 men and 58 women; mean age, 58.16 ± 8.45 years) retrospectively underwent magnetic resonance DWI thermometry to estimate brain intraventricular temperature (T_v). Subjects were divided into three subgroups in light of their ages. The tested inflammatory markers included plasma nuclear DNA, m

SUBMITTER: Chen HL 

PROVIDER: S-EPMC7196953 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature