Sex-Based Differences in Cortical and Subcortical Development in 436 Individuals Aged 4-54 Years.

ABSTRACT: Sex-based differences in brain development have long been established in ex vivo studies. Recent in vivo studies using magnetic resonance imaging (MRI) have offered considerable insight into sex-based variations in brain maturation. However, reports of sex-based differences in cortical volumes and thickness are inconsistent. We examined brain maturation in a cross-sectional, single-site cohort of 436 individuals (201 [46%] males) aged 4-54 years (median = 16 years). Cortical thickness, cortical surface area, subcortical surface area, volumes of the cerebral cortex, white matter (WM), cortical and subcortical gray matter (GM), including the thalamic subnuclei, basal ganglia, and hippocampi were calculated using automatic segmentation pipelines. Subcortical structures demonstrated distinct c

SUBMITTER: Duerden EG 

PROVIDER: S-EPMC7197069 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature