Heritability and Cognitive Relevance of Structural Brain Controllability.

ABSTRACT: Cognition and behavior are thought to emerge from the connections and interactions among brain regions. The precise nature of these relationships remains elusive. Here we use tools provided by network control theory to determine how the structural connectivity profile of brain regions may shape individual variation in cognition. In a cohort of healthy young adults (n = 1066), we computed two fundamental brain regional control patterns, average and modal controllability, which index the degree of influence of a region over others. We first established that regional brain controllability measures were both reproducible and heritable. Regions with controllability profiles theoretically conducive to facilitating multiple cognitive operations were over-represented in higher-order resting-state

SUBMITTER: Lee WH 

PROVIDER: S-EPMC7197079 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature