N,O-Nucleoside Analogues: Metabolic and Apoptotic Activity.

ABSTRACT: Two new families of N,O-nucleoside analogues containing the anthracene moiety introduced through the nitrosocarbonyl ene reaction with allylic alcohols were prepared. The core structure is an isoxazolidine heterocycle that introduces either atom either a phenyl ring or dimethyl moiety at the C3 carbon. Different heterobases were inserted at the position 5 of the heterocyclic ring. One of the synthesized compounds demonstrated a good capacity to induce cell death and an appreciable nuclear fragmentation was evidenced in treated cells.

SUBMITTER: Marraffa A 

PROVIDER: S-EPMC7197084 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature