Pain-Evoked Reorganization in Functional Brain Networks.

ABSTRACT: Recent studies indicate that a significant reorganization of cerebral networks may occur in patients with chronic pain, but how immediate pain experience influences the organization of large-scale functional networks is not yet well characterized. To investigate this question, we used functional magnetic resonance imaging in 106 participants experiencing both noxious and innocuous heat. Painful stimulation caused network-level reorganization of cerebral connectivity that differed substantially from organization during innocuous stimulation and standard resting-state networks. Noxious stimuli increased somatosensory network connectivity with (a) frontoparietal networks involved in context representation, (b) "ventral attention network" regions involved in motivated action selection, and (c)

SUBMITTER: Zheng W 

PROVIDER: S-EPMC7197093 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature