Diaphragmatic paralysis: Evaluation in infants with congenital Zika syndrome.

ABSTRACT:

Background

Paralysis of the diaphragm in newborn infants can lead to recurrent infections and life-threatening respiratory insufficiency. The clinical diagnosis of unilateral diaphragmatic paralysis has been reported in infants with laboratory evidence of congenital Zika virus infection and/or the congenital Zika syndrome (CZS) phenotype but no evaluation of phrenic nerve function has been described. All reported infants have had accompanying arthrogryposis. High infant mortality is reported.

Methods

The causal mechanism of congenital diaphragmatic paralysis was evaluated in three infants with arthrogryposis as a manifestation of CZS (two of the three infants had laboratory evidence of ZIKV infection shortly after birth; the remaining infant had negative serology for ZIKV wh

SUBMITTER: van der Linden V 

PROVIDER: S-EPMC7197100 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature