The predictive role of serum calprotectin on mortality in hemodialysis patients with high phosphoremia.

ABSTRACT:

Background

The inflammatory mediator calprotectin (CPT, myeloid-related protein 8/14) is known as an endogenous ligand contributing to pathophysiology in inflammatory diseases. Serum CPT reportedly became a potential biomarker in these conditions, though there is no report predicting the prognosis in hemodialysis patients. The aim of this study is to investigate the predictive role of serum CPT on mortality in hemodialysis patients.

Methods

We conducted a multicenter, observational cohort study of 388 Japanese subjects undergoing hemodialysis. Serum CPT were measured using an ELISA. The potential associations between serum CPT and clinical variables were cross-sectionally examined. Multivariate Cox regression was used to estimate the association between serum CPT, high-sensi

SUBMITTER: Kanki T 

PROVIDER: S-EPMC7197146 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature