Fecal microbiota composition is linked to the postoperative disease course in patients with Crohn's disease.

ABSTRACT:

Background

The role of the fecal microbiota composition for the postoperative disease course of patients with Crohn's disease (CD) who have undergone ileocecal resection remains to be established. In this study, we investigated if the fecal microbiota composition, determined by a high throughput test quantifying a pre-selected set of bacteria, is associated with the postoperative disease course of CD patients.

Methods

Fecal samples were obtained from healthy subjects as well as from CD patients, 3-10 weeks and 1 year after ileocaecal resection. The fecal microbial composition was analyzed by Genetic Analysis GA-map Dysbiosis test, targeting ≥300 bacteria on different taxonomic levels. Postoperative disease status was assessed endoscopically according to Rutgeerts scoring sys

SUBMITTER: Strombeck A 

PROVIDER: S-EPMC7197162 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature