Polymorphisms in interferon pathway genes and risk of Mycobacterium tuberculosis infection in contacts of tuberculosis cases in Brazil.

ABSTRACT:

Background

Host genetic polymorphisms may be important in determining susceptibility to Mycobacterium tuberculosis (Mtb) infection, but their role is not fully understood. Detection of microbial DNA and activation of type I interferon (IFN) pathways regulate macrophage responses to Mtb infection.

Methods

We examined whether seven candidate gene SNPs were associated with tuberculin skin test (TST) positivity in close contacts of microbiologically confirmed pulmonary TB patients in Brazil. Independent associations with TST positivity were tested using multivariable logistic regression (using genotypes and clinical variables) and genetic models.

Results

Among 482 contacts of 145 TB index cases, 296 contacts were TST positive. Multivariable regression analysis adjusted fo

SUBMITTER: Cubillos-Angulo JM 

PROVIDER: S-EPMC7197195 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature