Black raspberries suppress pancreatic cancer through modulation of NKp46⁺, CD8⁺, and CD11b⁺ immune cells.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with a low survival rate (9%). Epidemiologic studies show that healthy dietary patterns enriched of fruits and vegetables lower the risk of PDAC. We previously showed that supplementing black raspberries (BRBs) to patients with colorectal cancer increased tumor-infiltrating NK cells and their cytotoxicity. We aimed to determine whether BRBs combat PDAC by modulating cancer immunity. NOD.SCID mice lacking T and B cells were injected with human Panc-1-Luc cells orthotopically, and immunocompetent Kras ^LSL.G12D/+ -Trp53 ^LSL.R172H/+ -Pdx-1-Cre mice were fed BRBs. Peripheral blood mononuclear cells (PBMCs) from PDAC patients were treated with butyrate, a microbial metabolite of BR

SUBMITTER: Pan P 

PROVIDER: S-EPMC7197210 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature