MAKAPβ signalosomes - A nodal regulator of gene transcription associated with pathological cardiac remodeling.

ABSTRACT: Striated myocytes compose about half of the cells of the heart, while contributing the majority of the heart's mass and volume. In response to increased demands for pumping power, including in diseases of pressure and volume overload, the contractile myocytes undergo non-mitotic growth, resulting in increased heart mass, i.e. cardiac hypertrophy. Myocyte hypertrophy is induced by a change in the gene expression program driven by the altered activity of transcription factors and co-repressor and co-activator chromatin-associated proteins. These gene regulatory proteins are subject to diverse post-translational modifications and serve as nuclear effectors for intracellular signal transduction pathways, including those controlled by cyclic nucleotides and calcium ion. Scaffold proteins contri

SUBMITTER: Dodge-Kafka K 

PROVIDER: S-EPMC7197268 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature