Real-World Nonmotor Changes in Patients with Parkinson's Disease and Motor Fluctuations: J-FIRST.

ABSTRACT:

Background

Nonmotor symptoms (NMSs) of Parkinson's disease (PD) impair health-related quality of life.

Objectives

To identify changes in NMSs during 52 weeks in Japanese PD patients exhibiting motor fluctuations.

Methods

In PD patients with ≥1 NMS and wearing-off, changes in total/subscore of the Movement Disorder Society Unified PD Rating Scale (MDS-UPDRS) Part I and 8-item PD Questionnaire were assessed. Group-based trajectory models were used to characterize longitudinal patterns of MDS-UPDRS Part I.

Results

Data from 996 patients were analyzed. MDS-UPDRS Part I subscores for cognitive function decreased linearly over time. Total and subscores for apathy and lightheadedness on standing significantly deteriorated with fluctuations, whereas other subscores flu

SUBMITTER: Watanabe H 

PROVIDER: S-EPMC7197319 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature