Autophagy promotes mammalian survival by suppressing oxidative stress and p53.

ABSTRACT: Autophagy captures intracellular components and delivers them to lysosomes for degradation and recycling. Conditional autophagy deficiency in adult mice causes liver damage, shortens life span to 3 mo due to neurodegeneration, and is lethal upon fasting. As autophagy deficiency causes p53 induction and cell death in neurons, we sought to test whether p53 mediates the lethal consequences of autophagy deficiency. Here, we conditionally deleted Trp53 (p53 hereafter) and/or the essential autophagy gene Atg7 throughout adult mice. Compared with Atg7^Δ/Δ mice, the life span of Atg7^Δ/Δp53^Δ/Δ mice was extended due to delayed neurodegeneration and resistance to death upon fasting. Atg7 also suppres

SUBMITTER: Yang Y 

PROVIDER: S-EPMC7197357 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature