Bacterial Translocation and Risk of Liver Cancer in a Finnish Cohort.

ABSTRACT:

Background

Elevated systemic exposure to gut-derived bacterial products has been associated with hepatic inflammation and chronic liver diseases, potentially increasing the risk of liver cancer. However, only one prior study prospectively examined exposure to bacterial products in the circulation and risk of liver cancer, with a relatively limited coverage of biomarkers.

Methods

We conducted a nested case-control study (224 liver cancer cases and 224 matched controls) in a large cohort of Finnish male smokers followed from baseline (1985-1988) to 2014. The associations between a panel of biomarkers for bacterial translocation and the risk of liver cancer were assessed using multivariable-adjusted conditional logistic regression. The biomarkers included immunoglobulin (Ig) A,

SUBMITTER: Yang B 

PROVIDER: S-EPMC7197395 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature