Strengthened Temporal Coordination within Pre-existing Sequential Cell Assemblies Supports Trajectory Replay.

ABSTRACT: A central goal in learning and memory research is to reveal the neural substrates underlying episodic memory formation. The hallmark of sequential spatial trajectory learning, a model of episodic memory, has remained equivocal, with proposals ranging from de novo creation of compressed sequential replay from blank slate networks to selection of pre-existing compressed preplay sequences. Here, we show that increased millisecond-timescale activation of cell assemblies expressed during de novo sequential experience and increased neuronal firing rate correlations can explain the difference between post-experience trajectory replay and robust preplay. This increased activation results from an improved neuronal tuning to specific cell assemblies, higher recruitment of experience-tuned neurons in

SUBMITTER: Farooq U 

PROVIDER: S-EPMC7197404 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature