Lactate induces PD-L1 in HRASG12V-positive oropharyngeal squamous cell carcinoma.

ABSTRACT: Intratumoral lactate production negatively correlates with survival and tumor clearance in the setting of human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV-positive OPSCC). Robust anti-tumor immune activity is required for tumor clearance in human patients and animal models of this disease, and intratumoral lactate interferes with this process. While lactate is known to directly inhibit T cell activity, recent evidence has demonstrated that lactate can affect gene expression in multiple cell types. We therefore sought to determine if lactate in the tumor microenvironment could aid immune evasion by inducing the expression of immune checkpoint co-inhibitors. Using a mouse cell line transformed with HPV16 E6, E7, and HRASG12V, we determined that OPSCC cells carrying th

SUBMITTER: Verma AK 

PROVIDER: S-EPMC7197448 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature