Titration of Medical Therapy for Heart Failure With Reduced Ejection Fraction.

ABSTRACT:

Background

Guidelines recommend that patients with heart failure with reduced ejection fraction (HFrEF) have medical therapy titrated to target doses derived from clinical trials, as tolerated. The degree to which titration occurs in contemporary U.S. practice is unknown.

Objectives

This study sought to characterize longitudinal titration of HFrEF medical therapy in clinical practice and to identify associated factors and reasons for medication changes.

Methods

Among 2,588 U.S. outpatients with chronic HFrEF in the CHAMP-HF (Change the Management of Patients with Heart Failure) registry with complete medication data and no contraindications to medical therapy, use and dose of angiotensin-converting enzyme inhibitor (ACEI)/angiotensin II receptor blocker (ARB), angiote

SUBMITTER: Greene SJ 

PROVIDER: S-EPMC7197490 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature