Adipose tissue dendritic cell signals are required to maintain T cell homeostasis and obesity-induced expansion.

ABSTRACT: Adipose tissue derived chronic inflammation is a critical component of obesity induced type II diabetes. Major histocompatibility complex II (MHCII) mediated T cell activation within adipose tissue is one mechanism that contributes to this phenotype. However, the contribution of dendritic cells as professional antigen presenting cells in adipose issue has not previously been explored. Using Itgax^Cre x MHCII^fl/fl (M11cKO) mice we observed adipose tissue specific changes in adipose tissue leukocytes. While there was a complete knockout of MHCII in dendritic cells, MHCII was also absent on the majority of macrophages. This resulted in reduction of TCR expression in CD4⁺ T cells in obese adipose tissue, and an increase in CD8⁺ and CD4⁺ CD8

SUBMITTER: Porsche CE 

PROVIDER: S-EPMC7197735 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature