The association between normal lung function and peak oxygen uptake in patients with exercise intolerance and coronary artery disease.

ABSTRACT: In coronary artery disease (CAD), exercise intolerance with reduced oxygen uptake at peak exercise (VO2peak) is assumed to primarily reflect cardiovascular limitation. However, oxygen transport and utilization depends on an integrated organ response, to which the normal pulmonary system may influence overall capacity. This study aimed to investigate the associations between normal values of lung function measures and VO2peak in patients with exercise intolerance and CAD. We hypothesized that forced expiratory lung volume in one second (FEV1), transfer factor of the lung for carbon monoxide (TLCO) and TLCO/alveolar volume (TLCO/VA) above lower limits of normal (LLN) are associated with VO2peak in these patients. We assessed patients with established CAD (n = 93; 21 women) referred for evalu

SUBMITTER: Rasch-Halvorsen O 

PROVIDER: S-EPMC7197783 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature