Frontiers in Intravital Multiphoton Microscopy of Cancer.

ABSTRACT:

Background

Cancer is a highly complex disease which involves the co-operation of tumor cells with multiple types of host cells and the extracellular matrix. Cancer studies which rely solely on static measurements of individual cell types are insufficient to dissect this complexity. In the last two decades, intravital microscopy has established itself as a powerful technique that can significantly improve our understanding of cancer by revealing the dynamic interactions governing cancer initiation, progression and treatment effects, in living animals. This review focuses on intravital multiphoton microscopy (IV-MPM) applications in mouse models of cancer.

Recent findings

IV-MPM studies have already enabled a deeper understanding of the complex events occurring in cancer, at t

SUBMITTER: Perrin L 

PROVIDER: S-EPMC7197974 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature