Transcriptional regulators and regulatory pathways involved in prostate gland adaptation to a hypoandrogen environment.

ABSTRACT: Anti-androgen therapies, including orchiectomy, are effective at promoting prostate cancer remission, but are followed by progression to the more aggressive castration-resistant prostate cancer (CRPC). Castration promotes gland and tumor shrinkage. However, prostate adaptation to androgen deprivation involves striking parallel events, all requiring changes in gene expression. We hypothesized that transcription factors (TF) and other transcription-related genes are needed to orchestrate those changes. In this work, downstream analysis using bioinformatic tools and published microarray data allowed us to identify sixty transcriptional regulators (including 10 TF) and to integrate their function in physiologically relevant networks. Functional associations revealed a connection between Arnt,

SUBMITTER: Nishan U 

PROVIDER: S-EPMC7198032 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature