Toward an Evolutionarily Appropriate Null Model: Jointly Inferring Demography and Purifying Selection.

ABSTRACT: The question of the relative evolutionary roles of adaptive and nonadaptive processes has been a central debate in population genetics for nearly a century. While advances have been made in the theoretical development of the underlying models, and statistical methods for estimating their parameters from large-scale genomic data, a framework for an appropriate null model remains elusive. A model incorporating evolutionary processes known to be in constant operation, genetic drift (as modulated by the demographic history of the population) and purifying selection, is lacking. Without such a null model, the role of adaptive processes in shaping within- and between-population variation may not be accurately assessed. Here, we investigate how population size changes and the strength of purifyin

SUBMITTER: Johri P 

PROVIDER: S-EPMC7198275 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature