Could vitamin D reduce obesity-associated inflammation? Observational and Mendelian randomization study.

ABSTRACT:

Background

Obesity is associated with inflammation but the role of vitamin D in this process is not clear.

Objectives

We aimed to assess the associations between serum 25-hydroxyvitamin D [25(OH)D], BMI, and 16 inflammatory biomarkers, and to assess the role of vitamin D as a potential mediator in the association between higher BMI and inflammation.

Methods

Northern Finland Birth Cohort 1966 (NFBC1966) 31-y data on 3586 individuals were analyzed to examine the observational associations between BMI, 25(OH)D, and 16 inflammatory biomarkers. Multivariable regression analyses and 2-sample regression-based Mendelian randomization (MR) mediation analysis were performed to assess any role of vitamin D in mediating a causal effect of BMI on inflammatory biomarkers [soluble i

SUBMITTER: Palaniswamy S 

PROVIDER: S-EPMC7198294 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature