Plasma Ceramide Species Are Associated with Diabetes Risk in Participants of the Strong Heart Study.

ABSTRACT:

Background

Few studies have assessed the associations of ceramides and sphingomyelins (SMs) with diabetes in humans.

Objective

We assessed associations of 15 circulating ceramides and SM species with incident diabetes in 2 studies.

Methods

The analysis included 435 American-Indian participants from the Strong Heart Study (nested case-control design for analyses; mean age: 57 y; 34% male; median time until diabetes 4.3 y for cases) and 1902 participants from the Strong Heart Family Study (prospective design for analyses; mean age: 37 y; 39% male; median 12.5 y of follow-up). Sphingolipid species were measured using stored plasma samples by sequential LC and MS. Using logistic regression and parametric survival models within studies, and an inverse-variance-weighted met

SUBMITTER: Fretts AM 

PROVIDER: S-EPMC7198314 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature