Transarterial Chemoembolization in a Woodchuck Model of Hepatocellular Carcinoma.

ABSTRACT:

Purpose

To assess the feasibility of transarterial chemoembolization with drug-eluting embolic (DEE) microspheres in a woodchuck model of hepatocellular carcinoma (HCC).

Materials and methods

Nine woodchucks were studied: 4 normal animals and 5 animals infected with woodchuck hepatitis virus in which HCC had developed. Three animals with HCC underwent multidetector CT. A 3-F sheath was introduced into the femoral artery, and the hepatic arteries were selectively catheterized with 2.0-2.4-F microcatheters. Normal animals underwent diagnostic angiography and bland embolization. Animals with HCC underwent DEE transarterial chemoembolization with 70-150-μm radiopaque microspheres loaded with 37.5 mg doxorubicin per milliliter. Cone-beam CT and multidetector CT were performed. Fo

SUBMITTER: Pritchard WF 

PROVIDER: S-EPMC7198364 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature