Predictive Value of ¹⁸F-Florbetapir and ¹⁸F-FDG PET for Conversion from Mild Cognitive Impairment to Alzheimer Dementia.

ABSTRACT: The present study examined the predictive values of amyloid PET, ¹⁸F-FDG PET, and nonimaging predictors (alone and in combination) for development of Alzheimer dementia (AD) in a large population of patients with mild cognitive impairment (MCI). Methods: The study included 319 patients with MCI from the Alzheimer Disease Neuroimaging Initiative database. In a derivation dataset (n = 159), the following Cox proportional-hazards models were constructed, each adjusted for age and sex: amyloid PET using ¹⁸F-florbetapir (pattern expression score of an amyloid-β AD conversion-related pattern, constructed by principle-components analysis); ¹⁸F-FDG PET (pattern expression score of a previously defined ¹⁸F-FDG-based AD conversion-related pat

SUBMITTER: Blazhenets G 

PROVIDER: S-EPMC7198373 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature