Multimodality Imaging of Inflammation and Ventricular Remodeling in Pressure-Overload Heart Failure.

ABSTRACT: Inflammation contributes to ventricular remodeling after myocardial ischemia, but its role in nonischemic heart failure is poorly understood. Local tissue inflammation is difficult to assess serially during pathogenesis. Although ¹⁸F-FDG accumulates in inflammatory leukocytes and thus may identify inflammation in the myocardial microenvironment, it remains unclear whether this imaging technique can isolate diffuse leukocytes in pressure-overload heart failure. We aimed to evaluate whether inflammation with ¹⁸F-FDG can be serially imaged in the early stages of pressure-overload-induced heart failure and to compare the time course with functional impairment assessed by cardiac MRI. Methods: C57Bl6/N mice underwent transverse aortic constriction (TAC) (n =

SUBMITTER: Glasenapp A 

PROVIDER: S-EPMC7198376 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature