Salivary lactate and 8-isoprostaglandin F_2α as potential non-invasive biomarkers for monitoring heart failure: a pilot study.

ABSTRACT: Heart failure (HF) is a cardiovascular disease affecting about 26 million people worldwide costing about $100 billons per year. HF activates several compensatory mechanisms and neurohormonal systems, so we hypothesized that the concomitant monitoring of a panel of potential biomarkers related to such conditions might help predicting HF evolution. Saliva analysis by point-of-care devices is expected to become an innovative and powerful monitoring approach since the chemical composition of saliva mirrors that of blood. The aims of this study were (i) to develop an innovative procedure combining MEPS with UHPLC-MS/MS for the simultaneous determination of 8-isoprostaglandin F_2α and cortisol in saliva and (ii) to monitor lactate, uric acid, TNF-α, cortisol, α-amylase and 8-isoprostag

SUBMITTER: Ghimenti S 

PROVIDER: S-EPMC7198483 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature