Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.

ABSTRACT: The thymus supports multiple αβ T cell lineages that are functionally distinct, but mechanisms that control this multifaceted development are poorly understood. Here we examine medullary thymic epithelial cell (mTEC) heterogeneity and its influence on CD1d-restricted iNKT cells. We find three distinct mTEC^low subsets distinguished by surface, intracellular and secreted molecules, and identify LTβR as a cell-autonomous controller of their development. Importantly, this mTEC heterogeneity enables the thymus to differentially control iNKT sublineages possessing distinct effector properties. mTEC expression of LTβR is essential for the development thymic tuft cells which regulate NKT2 via IL-25, while LTβR controls CD104⁺CCL21⁺ mTEC^low that are capab

SUBMITTER: Lucas B 

PROVIDER: S-EPMC7198500 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature