Characteristics and outcomes of patients with therapy-related acute myeloid leukemia with normal karyotype.

ABSTRACT: Normal karyotype in therapy-related acute myeloid leukemia (t-AML) is rare and the relative contribution of prior exposure to chemotherapy or radiotherapy to outcomes in these patients remains uncertain. We performed a retrospective study of 742 patients with newly diagnosed AML and normal karyotype (t-AML, n?=?61, and non-t-AML, n?=?681). Patients with t-AML were older but had a similar mutational profile compared to those with non-t-AML. Overall survival (OS) and relapse-free survival (RFS) were significantly worse for patients with t-AML (P?

SUBMITTER: Samra B 

PROVIDER: S-EPMC7198507 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature