Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts.

ABSTRACT: Cell fusion occurs when several cells combine to form a multinuclear aggregate (syncytium). In human placenta, a syncytialized trophoblast (syncytiotrophoblast) layer forms the primary interface between maternal and fetal tissue, facilitates nutrient and gas exchange, and produces hormones vital for pregnancy. Syncytiotrophoblast development occurs by differentiation of underlying progenitor cells called cytotrophoblasts, which then fuse into the syncytiotrophoblast layer. Differentiation is associated with chromatin remodeling and specific changes in gene expression mediated, at least in part, by histone acetylation. However, the epigenetic regulation of human cytotrophoblast differentiation and fusion is poorly understood. In this study, we found that human syncytiotrophoblast developmen

SUBMITTER: Jaju Bhattad G 

PROVIDER: S-EPMC7198514 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature