Ontology highlight
ABSTRACT:
SUBMITTER: Kratochvilova A
PROVIDER: S-EPMC7198622 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Scientific reports 20200504 1
Caspases are proteases traditionally associated with inflammation and cell death. Recently, they have also been shown to modulate cell proliferation and differentiation. The aim of the current research was to search for osteogenic molecules affected by caspase inhibition and to specify the individual caspases critical for these effects with a focus on proapoptotic caspases: caspase-2, -3, -6, -7, -8 and -9. Along with osteocalcin (Ocn), general caspase inhibition significantly decreased the expr ...[more]