Functional Use of Directional Local Field Potentials in the Subthalamic Nucleus Deep Brain Stimulation.

ABSTRACT:

Background

Directional deep brain stimulation (DBS) technology aims to address the limitations, such as stimulation-induced side effects, by delivering selective, focal modulation via segmented contacts. However, DBS programming becomes more complex and time-consuming for clinical feasibility. Local field potentials (LFPs) might serve a functional role in guiding clinical programming.

Objective

In this pilot study, we investigated the spectral dynamics of directional LFPs in subthalamic nucleus (STN) and their relationship to motor symptoms of Parkinson's disease (PD).

Methods

We recorded intraoperative STN-LFPs from 8-contact leads (Infinity-6172, Abbott Laboratories, Illinois, United States) in 8 PD patients at rest. Directional LFPs were referenced to their common

SUBMITTER: Telkes I 

PROVIDER: S-EPMC7198898 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature