Comparative Effectiveness of Antibiotic Treatment Duration in Children With Pyelonephritis.

ABSTRACT:

Importance

National guidelines recommend treating children with pyelonephritis for 7 to 14 days of antibiotic therapy, yet data are lacking to suggest a more precise treatment duration.

Objective

To compare the clinical outcomes of children receiving a short-course vs a prolonged-course of antibiotic treatment for pyelonephritis.

Design, setting, and participants

Retrospective observational study using inverse probability of treatment weighted propensity score analysis of data from 5 hospitals in Maryland between July 1, 2016, and October 1, 2018. Participants were children aged 6 months to 18 years with a urine culture growing Escherichia coli, Klebsiella species, or Proteus mirabilis with laboratory and clinical criteria for pyelonephritis.

Exposures

Treatmen

SUBMITTER: Fox MT 

PROVIDER: S-EPMC7199115 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature