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Long-term Outcome of Pulmonary Vein Isolation Versus Amiodarone Therapy in Patients with Coexistent Persistent AF and Congestive Heart Failure.

ABSTRACT: Although pharmacological rhythm control of AF in patients with heart failure with reduced ejection fraction (HFrEF) does not seem to provide any benefit over rate control, catheter ablation of AF has been shown to improve clinical outcomes. These results can be explained with higher success rates of catheter ablation in restoring and maintaining sinus rhythm compared with antiarrhythmic drugs. In addition, pharmacotherapy is not void of side-effects, which are thought to offset its potential antiarrhythmic benefits. Therefore, efforts should be made towards optimisation of ablation techniques for AF in patients with HFrEF.

SUBMITTER: Faggioni M 

PROVIDER: S-EPMC7199124 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Long-term Outcome of Pulmonary Vein Isolation Versus Amiodarone Therapy in Patients with Coexistent Persistent AF and Congestive Heart Failure.

Faggioni Michela M   Della Rocca Domenico G DG   Mohanty Sanghamitra S   Trivedi Chintan C   Canpolat Ugur U   Gianni Carola C   Al-Ahmad Amin A   Horton Rodney R   Gallinghouse Gerald Joseph GJ   Burkhardt John David JD   Natale Andrea A  

Cardiac failure review 20200301

Although pharmacological rhythm control of AF in patients with heart failure with reduced ejection fraction (HFrEF) does not seem to provide any benefit over rate control, catheter ablation of AF has been shown to improve clinical outcomes. These results can be explained with higher success rates of catheter ablation in restoring and maintaining sinus rhythm compared with antiarrhythmic drugs. In addition, pharmacotherapy is not void of side-effects, which are thought to offset its potential ant  ...[more]

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