Functionalized 3-(5-ar-yloxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-1-(4-substituted-phen-yl)prop-2-en-1-ones: synthetic pathway, and the structures of six examples.

ABSTRACT: Five examples each of 3-(5-ar-yloxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-1-[4-(prop-2-yn-1-yl-oxy)phen-yl]prop-2-en-1-ones and the corresponding 1-(4-azido-phen-yl)-3-(5-ar-yloxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)prop-2-en-1-ones have been synthesized in a highly efficient manner, starting from a common source precursor, and structures have been determined for three examples of each type. In each of 3-[5-(2-chloro-phen-oxy)-3-methyl-1-phenyl-1H-pyrazol-4-yl]-1-[4-(prop-2-yn-1-yl-oxy)phen-yl]prop-2-en-1-one, C28H21ClN2O3, (Ib), the isomeric 3-[5-(2-chloro-phen-oxy)-3-methyl-1-phenyl-1H-pyrazol-4-yl]-1-[4-(prop-2-yn-1-yl-oxy)phen-yl]prop-2-en-1-one, (Ic), and 3-[3-methyl-5-(naphthalen-2-yl-oxy)-1-phenyl-1H-pyrazol-4-yl]-1-[4-(prop-2-yn-yloxy)phen-yl]prop-2-en-1-one, C32H24N2O3, (Ie), the mol-e

SUBMITTER: Kiran Kumar H 

PROVIDER: S-EPMC7199250 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature