Structural equation modeling the "control of gut overgrowth" in the prevention of ICU-acquired Gram-negative infection.

ABSTRACT:

Background

Conceptually, the "control of gut overgrowth" (COGO) is key in mediating prevention against infection with Gram-negative bacilli by topical antibiotic prophylaxis, a common constituent of selective digestive decontamination (SDD) regimens. However, the relative importance of the other SDD components, enteral and protocolized parenteral antibiotic prophylaxis, versus other methods of infection prevention and versus other contextual exposures cannot be resolved within individual studies.

Methods

Seven candidate generalized structural equation models founded on COGO concepts were confronted with Pseudomonas and Acinetobacter bacteremia as well as ventilator-associated pneumonia data derived from > 200 infection prevention studies. The following group-level exposures

SUBMITTER: Hurley JC 

PROVIDER: S-EPMC7199305 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature