Plasma volume expansion and capillary leakage of 20% albumin in burned patients and volunteers.

ABSTRACT:

Background

Burn injury is associated with a long-standing inflammatory reaction. The use of albumin solutions for plasma volume support is controversial because of concerns of increased capillary leakage, which could aggravate the commonly seen interstitial oedema.

Methods

In the present open controlled clinical trial, an intravenous infusion of 20% albumin at 3 mL/kg was given over 30 min to 15 burn patients and 15 healthy volunteers. Blood samples and urine were collected for 5 h. Plasma dilution, plasma albumin and colloid osmotic pressure were compared. Mass balance calculations were used to estimate plasma volume expansion and capillary leakage of fluid and albumin.

Results

The patients were studied between 4 and 14 (median, 7) days after the burn injury, which s

SUBMITTER: Zdolsek M 

PROVIDER: S-EPMC7199306 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature