Whole-genome homozygosity mapping reveals candidate regions affecting bull fertility in US Holstein cattle.

ABSTRACT:

Background

Achieving rapid genetic progress while maintaining adequate genetic diversity is one of the main challenges facing the dairy industry. The increase in inbreeding can be used to monitor the loss of genetic diversity. Inbreeding tends to increase the proportion of homozygous loci, some of which cause homozygosity of recessive alleles that results in reduced performance. This phenomenon is known as inbreeding depression and tends to be most prominent on fitness-related traits, such as male fertility. Traditionally, inbreeding has been monitored using pedigree information, or more recently, genomic data. Alternatively, it can be quantified using runs of homozygosity (ROH), i.e., contiguous lengths of homozygous genotypes observed in an individual's chromosome.

Results

SUBMITTER: Nani JP 

PROVIDER: S-EPMC7199307 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature