The metabolome as a link in the genotype-phenotype map for peroxide resistance in the fruit fly, Drosophila melanogaster.

ABSTRACT:

Background

Genetic association studies that seek to explain the inheritance of complex traits typically fail to explain a majority of the heritability of the trait under study. Thus, we are left with a gap in the map from genotype to phenotype. Several approaches have been used to fill this gap, including those that attempt to map endophenotype such as the transcriptome, proteome or metabolome, that underlie complex traits. Here we used metabolomics to explore the nature of genetic variation for hydrogen peroxide (H₂O₂) resistance in the sequenced inbred Drosophila Genetic Reference Panel (DGRP).

Results

We first studied genetic variation for H₂O₂ resistance in 179 DGRP lines and along with identifying the insulin signaling modulat

SUBMITTER: Harrison BR 

PROVIDER: S-EPMC7199327 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature