Pharmacokinetic and pharmacodynamic considerations in developing a response to the opioid epidemic.

ABSTRACT: Introduction: Opioids continue to be used widely for pain management. Widespread availability of prescription opioids has led to opioid abuse and addiction. Besides steps to reduce inappropriate prescribing, exploiting opioid pharmacology to make their use safer is important.Areas covered: This article discusses the pathology and factors underlying opioid abuse. Pharmacokinetic and pharmacodynamic properties affecting abuse liability of commonly abused opioids have been highlighted. These properties inform the development of ideal abuse deterrent products. Mechanisms and cost-effectiveness of available abuse deterrent products have been reviewed in addition to the pharmacology of medications used to treat addiction.Expert opinion: The opioid crisis presents unique chal

SUBMITTER: Balyan R 

PROVIDER: S-EPMC7199505 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature